WebThe p-ATR expression increased in head and neck squamous cell carcinoma cisplatin-resistant cells. VE-822 significantly enhanced the therapeutic effect in cisplatin resistant head and neck squamous cell carcinoma by inhibiting p-ATR expression in vivo and in vitro. WebSep 9, 2024 · Cells were treated with mTORi Torin1 or RAD001(10nM each) or with cisplatin (300ng/ml) for 3 days, fixed in 4% paraformaldehyde, permeabilized with 0.2% Triton X-100, followed by immunofluorescent analysis with RAD51 and γH2AX antibodies. ... Induction of ATR expression was associated with an ~40% increase in resistance to …
IJMS Free Full-Text Caffeine and Cisplatin Effectively Targets the ...
WebApr 1, 2024 · Triple-negative tumor cells, a malignant subtype of breast cancer, lack a biologically targeted therapy. Given its DNA repair inhibiting properties, caffeine has been shown to enhance the effectiveness of specific tumor chemotherapies. In this work, we have investigated the effects of caffeine, cisplatin, and a combination of the two as potential … WebApr 14, 2024 · Abstract. Ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase orchestrates DNA damage response and repair pathways stimulated by replicative stresses. Recent studies have established that pharmacological inhibition of ATR is clinically promising. As M1774 is an oral ATR inhibitor in clinical development, we explored the … rbc topsail rd
Discovery of ATR kinase inhibitor berzosertib (VX-970
WebThe ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer DNA damage is a key factor both in the evolution and treatment of cancer. Genomic instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations, while radiation and diverse genotoxic agents remain important, if imperfect, therapeutic … WebSep 5, 2011 · As in some clinical settings cisplatin constitutes the major therapeutic option, the development of chemosensitization strategies constitute a goal with important clinical … WebFeb 27, 2015 · Inhibitors of checkpoint kinases ATR, Chk1, and Wee1 are currently being tested in preclinical and clinical trials. Here, we review the basic principles behind the use of such inhibitors as anticancer agents, and particularly discuss their potential for … rbc to rbc wire