List of lysosomotropic agents
WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4. WebIntroduction. As a recognized food-grade preservative, sodium benzoate (SB), whose structure is shown in Fig. 1, is widely used in the food, cosmetic, and pharmaceutical industries [1–3].For example, in the food industry, SB is used in a variety of foods and beverages, such as salads, kimchi, carbonated beverages, jams, juices, and soy sauce, …
List of lysosomotropic agents
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Web1 aug. 2024 · Some lysosomotropic compounds used in experimental work on endolysosomal trafficking and function include the tricyclic antidepressants, imipramine …
WebDownload Table LogP and pKa values and molecular structures of the lysosomotropic drugs used in this work from publication: Lysosomal accumulation of anticancer drugs … WebAbstract. A sigma-2 receptor ligand siramesine induces lysosomal leakage and cathepsin-dependent death of cancer cells in vitro and displays potent anti-cancer …
WebThe use of lysosomotropic agents offers a new treatment possibility since they disrupt lysosomal membranes and can trigger a series of events leading to cell death. In addition, combining lysosome disrupting agents with targeted inhibitors can … Web24 mrt. 2024 · agents with lysosomotropic properties might also demonstrate clinical effectiveness in the treatment of COVID-19. In this review, we discuss commonly used …
Web9 sep. 2024 · May 2024 · Methods in molecular biology (Clifton, N.J.) Tomoki Kuwahara. Leucine-rich repeat kinase 2 (LRRK2) is a causative gene product of autosomal-dominant Parkinson’s disease and has been ...
Web6 jan. 2024 · Cell Death & Disease - Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response Skip to … immunotherapy for cancer bostonWeb30 okt. 2024 · The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the … immunotherapy for b cell lymphomaWeb6 aug. 2024 · Lysosomotropic detergents are well-studied LMP-promoting agents that function by directly disrupting membrane dynamics leading to organelle leakage or by impairing function of lysosomal lipases . Under physiological conditions, LDCD contributes to tissue remodeling during mammary gland involution ( 160 ) and regulates immune cell … immunotherapy for cmlWeb7 jun. 2024 · Lysosomal VPS18 as a potential target for the reversal of chemoresistance by a novel lysosomotropic agent RDN. Data are the mean ± SD; * p < 0.05, ** p < 0.01, and *** p < 0.001 Full size image immunotherapy for cllWebWith the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria … immunotherapy for catsWeb7 apr. 2024 · The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory … immunotherapy for autoimmune hepatitisWeb19 okt. 2024 · Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in individuals receiving long term drug treatment.Experimental … immunotherapy for cancer breast