Pltp inflammation
WebbPLTP deficient mice depicts lowered susceptibility for atherosclerosis, whereas, PLTP transgenic mice have more atherosclerosis. In humans, an increased PLTP activity been … Webb26 jan. 2024 · Phospholipid transfer protein (PLTP), a member of lipid transfer protein family, is an important protein involved in lipid metabolism in the circulation. This article …
Pltp inflammation
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Webb16 aug. 2012 · Moreover, PLTP activity is positively correlated with heart failure due to coronary artery ischemia [ 82] and low HDL levels [ 83 ]. Contradictorily, one study has shown that low PLTP is a risk factor for peripheral atherosclerosis [ 84 ]. Webb1 aug. 2024 · PLTP is a member of the lipid transfer/lipopolysaccharide-binding protein (LT/LBP) or BPI-like gene family, which also includes cholesteryl ester transfer protein …
Webb18 okt. 2024 · PLTP also promotes the uptake and transport of cholesterol from peripheral cells to the liver 26. Additionally, PLTP has anti-inflammatory effects, via ABCA1 … Webb5 dec. 2013 · To assess how PLTP affected inflammatory responses in a lung injury model, PLTP siRNA or recombinant protein was administered to the lungs of mice prior to LPS challenge. Silencing PLTP at baseline caused a 68% increase in inflammatory cell infiltration, a 120 and 340% increase in ERK and NF-κB activation, and increased MMP-9, …
Webb9 feb. 2016 · The effects of PLTP on pro-inflammatory cytokines level induced by LPS in macrophage. (A–C) After 200 ng/mL of LPS stimulation for 24 h, media from cultured BMDM of WT or PLTP−/− were harvested and conducted for TNF-α, IL-6, and IFN-γ quantization by ELISA. WebbInflammation kan uppstå av en rad andra orsaker, som klämskador, kyla eller av kemiska ämnen. Inflammation kan också ta sig olika skepnader. Den kan vara akut och kraftfull, som vid olika infektioner som sepsis, meningit eller ”cytokinstormen” vid covid-19. Immunförsvaret kan också vara oförmöget att agera, vilket kallas för ...
WebbAfter an updated overview of the role of PLTP in lipid transfer, lipoprotein metabolism and related diseases, current knowledge of its impact on inflammation, infection and sepsis is critically ...
WebbLipid transport, Transport. Gene summary (Entrez)i. Useful information about the gene from Entrez. The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded prote in transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). greenbottle blue tarantula factsWebb30 nov. 2009 · Phospholipid transfer protein (PLTP) is an important modulator of lipoprotein metabolism, including interparticle phospholipid transfer, remodeling of HDL, cholesterol and phospholipid efflux from peripheral tissues, and the production of hepatic VLDL. PLTP also plays an important role in inflammation and oxidative stress. green bottle blue care sheetWebb15 jan. 2015 · Furthermore, PLTP exerts several actions at the cellular level, including effects on the nuclear factor-κB pathway in macrophages with functional consequences for vascular biology and inflammation [1], [2]. Of additional interest, common genetic variations in PLTP associate with glycemic traits [11]. green bottle alcoholflowers st. peters moWebb5 sep. 2016 · To investigate the effect of phospholipid transfer protein (PLTP) on the cigarette smoke extract (CSE)-induced production of interleukin-8 (IL-8) in human pulmonary epithelial cells, male Wistar rats were exposed to air and cigarette smoke (n = 10/exposure) for 6 h/day on three consecutive days.Their lungs were sectioned and … flowers st pete beach flWebbadvances came in support of a complex role of PLTP in the regulation of the inflammatory response, both with pro-inflammatory or anti-inflammatory properties. The aim of the pres-ent study was to decipher the role of PLTP in joint inflammation and to assess its relevance in the context of RA. PLTP expression was examined by western-blot and by ... green bottle blue humidityWebb16 juli 2015 · Plasma phospholipid transfer protein (PLTP), a homolog of CETP, circulates in plasma and facilitates the transfer of phospholipids and cholesterol among lipoproteins [ 19 – 27 ]. It can mediate the conversion of HDL into larger and smaller particles [ 28, 29] and generate pre-β HDL in the process [ 30 ]. green bottle blue tarantula growth rate