Sm-a-actin

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August undefined, 2024

Webbwith the Rho kinase inhibitor Y-27632 (10 mM) or actin polymerization with latrunculin B (0.5 mM) significantly decreased the activity of SM22 and SM a-actin promot-ers. In contrast, increasing actin polymerization with jasplakinolide (0.5 mM) increased SM22 and SM a-actin promoter activity by 22-fold and 13-fold, respectively. WebbThe cell extracts were analyzed by Western blotting with antibodies against SM-a-actin, SRF, Smad2, Smad4, or b-actin as indicated. (B) Serumstarved human lung fibroblasts …

Developmental changes in isoactin expression in rat aortic …

Webb5 feb. 2024 · Actins是球状多功能蛋白质的一个家族，形成微丝。 ACTA2是6种不同肌动蛋白亚型之一，参与平滑肌的收缩。 ACTA2（和所有actins一样）极其保守，几乎在所有哺乳动物中都有发现。在人类中，ACTA2由位于10q22-q24的ACTA2基因编码。该基因突变导致多种血管疾病，如胸主动脉疾病、冠状动脉疾病、中风、烟雾病和多系统平滑肌功能障 … WebbA smooth muscle antibody (SMA) is a type of antibody known as an autoantibody. Normally, your immune system makes antibodies to attack foreign substances like … how long ago was the constitution made

Anti-Alpha-Smooth Muscle Actin Antibodies Invitrogen

WebbSM a-actin promoter is regulated through combinatorial interactions between different factors. Transforming growth factor-b induced activity of the 125-bp rat SM a-actin promoter is dependent on both an intact transforming growth factor-bcontrol element and intact CArG boxes.18 Addition-ally, the homeodomain factor MHox activates SM a-actin Webb30 maj 2024 · Western blot results showed that the expression of SM-a-actin and SM-22a was increased, whereas the expression of MMP-2 and TNF-α was decreased in VSMCs treated with 3-MA, in relative to shear stress group (Fig. 4), suggesting that the induction of autophagy could partially block the phenotypic transition of VSMCs. WebbAlpha smooth muscle actin antibody (ab5694) stains smooth muscle cells in vessel walls, gut wall, and myometrium. Myoepithelial cells in breast and salivary gland are also … how long ago was the bible wrote

Actin, alpha-Smooth Muscle - FITC monoclonal antibody ...

Human Activin-A Is Expressed in the Atherosclerotic Lesion and Promotes …

Webb15 jan. 1992 · Addition of sequence between positions −151 and −257 (p257CAT) resulted in a 7-fold increase in chloramphenicol acetyltransferase activity over that of p151CAT in rat SMC, but not in chicken SMC. A genomic clone encoding the rat smooth muscle alpha-actin gene was isolated, and the 5'-flanking region was partially characterized. how long ago was the black deathACTA2 (commonly referred to as alpha-smooth muscle actin or α-SMA) is often used as a marker of myofibroblast formation. Studies have shown that ACTA2 is associated with TGF-β pathway that enhances contractile properties of hepatic stellate cells leading to liver fibrosis and cirrhosis . Visa mer ACTA2 (actin alpha 2) is an actin protein with several aliases including alpha-actin, alpha-actin-2, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA). Actins are a Visa mer • Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biologica. 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639. S2CID Visa mer • GeneReviews/NIH/NCBI/UW entry on Thoracic Aortic Aneurysms and Aortic Dissections • Human ACTA2 genome location and ACTA2 gene details page in the Visa mer how long ago was the golden age

"Webbalpha-Smooth muscle (alpha-sm) actin, an isoform typical of smooth muscle cells (SMC) and present in high amounts in vascular SMC, was demonstrated in the cytoplasm of … " - Sm-a-actin

Sm-a-actin

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WebbActin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells ( PubMed: 29581253 ). Actin exists in both … WebbStress may directly activate transcription of the α-SM actin gene, since application of force across integrin binding sites has been shown to up-regulate α-SM actin promoter activity. 52 As mentioned above, mechanical force alone is not generally sufficient to induce myofibroblast differentiation and other factors are needed to act in concert, specifically …

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WebbPulmonary lymphangioleiomyomatosis (LAM) is a rare genetic disease characterized by neoplastic growth of atypical smooth muscle-like LAM cells, destruction of lung parenchyma, obstruction of... Webbimmunocytochemical analysis using antibodies specific for either SM a-actin (Skalli et al., 1986) or SM myosin heavy chain (Kawamoto and Adelstein, 1987). Microscopic evaluation of a number of fields failed to uncover SM a-actin- or SM myosin heavy chain-negative cells (data not shown). Additionally, the expression of SM a-actin in

WebbThe Actin Alpha 2 (ACTA2) gene encoding smooth muscle aortic actin, was isolated and characterized. It was found that the ACTA2 gene contains at least 9 exons (7). Alpha smooth muscle actin appears to play an important functional role in myofibroblast contraction and migration. WebbTransforming growth factor (TGF)-b-induced expression of smooth muscle (SM)-a-actin is accompanied by expression and activation of serum response factor (SRF). (A) Human …

WebbOur Alpha-Smooth Muscle Actin monoclonal, polyclonal, recombinant monoclonal, cocktail and recombinant polyclonal antibodies are developed in Mouse, Rabbit and Goat. These antibodies have been verified by Relative expression and Cell treatment to confirm specificity to Alpha-Smooth Muscle Actin. Webb24 juni 2024 · Definition / general. Actin is a 43000 kDa ubiquitous protein found in all cells. Actins are involved in cell motility (alpha, smooth muscle) and the maintenance of the cytoskeleton (beta and gamma, all cells) …

Webbof SM a-actin expression involves a complex interaction of multiple positive and negative cis elements that act in a cell-type specific fashion.10–16 For example, a 547 bp SM a-actin promoter/CAT construct (p547CAT) had high activ-ity in cultured SMCs and in L6 skeletal myotubes, which are cell types that express SM a-actin in culture ...

Webb9 apr. 2024 · Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. Greve JN, et al. Eur J Cell Biol, 2024 Apr. PMID 35313204. A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers. how long ago was the dinosaur eraWebbSMC-specific marker genes including SM a-actin, SM myosin heavy chain, SM22, h-caldesmon, calponin, and telokin. The CArGs within any given SMC-specific promoter are … how long ago was the byzantine empireWebbα-Actinin 属于细胞骨架蛋白的血影蛋白家族。它最早被确认为肌动蛋白交联蛋白，在每个单体的氨基末端与肌动蛋白结合头形成反向平行同型二聚体。 α-actinin 可以与大量参与 … how long ago was the first organismWebb3 dec. 2007 · We identified 2 types of migrating cells with distinctive actin filament structures at the migrating front: type I (Figure (Figure5A), 5 A), cells with a large amount of F-actin stress fibers forming lamellum-like protrusions, and type II (Figure (Figure5A), 5 A), cells with a polarized morphology, a ruffling lamellipodium at the leading edge facing the … how long ago was the flood in the bibleWebb7 okt. 2024 · At E16.5, the expression of SM α-actin cannot detect in both control group and L-NAME treated group (Data not shown). At E17.5, SM α-actin expression observed in large vessels, as well as within ... how long ago was the first harry potter movieWebbSM a-actin, SM myosin heavy chain (MHC), and h1 calponin. However, induction of SM a-actin by TGF-bis not restricted to SMCs. A study by Shah et al4 demonstrated that TGF-b stimulated differentiation of neural crest cells into SMCs or SMC-like cells based on morphological criteria and the induction of SM a-actin and h1 calponin. Of particular how long ago was the exodusWebb1 mars 2003 · We hypothesized that ablation of smooth muscle α-actin (SM α-A), a contractile-cytoskeletal protein expressed in airway smooth muscle (ASM) cells, … how long ago was the cold war